Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094660 | 0.98 | MAPT (0.54) | MAPTHRH3GAAKMT2AMEN1 | |
| SCHEMBL3216979 | 0.78 | MEN1 (0.41) | KMT2AMEN1SIGMAR1L3MBTL1 | |
| Ethylene SCHEMBL11075789 | 0.77 | CHRM2 (0.43) | KMT2AMEN1CMA1SIGMAR1L3MBTL1 | |
| Ethylene SCHEMBL11704866 | 0.77 | LMNA (0.54) | MAPTKMT2AMEN1CMA1L3MBTL1 | |
| Ethylene SCHEMBL11096811 | 0.77 | GRIN1 (0.50) | GAAKMT2ASIGMAR1HSD11B1 | |
| SCHEMBL11098005 | 0.76 | AKT2 (0.48) | MAPTKMT2AMEN1CMA1SIGMAR1 | |
| SCHEMBL11073936 | 0.75 | KCNH2 (0.46) | MAPTKMT2AMEN1CMA1SIGMAR1 | |
| Ethylene SCHEMBL11803926 | 0.75 | MEN1 (0.52) | MAPTGAAKMT2AMEN1L3MBTL1 | |
| SCHEMBL11075865 | 0.75 | CMA1 (0.46) | KMT2AMEN1CMA1SIGMAR1L3MBTL1 | |
| Ethylene SCHEMBL11076270 | 0.74 | CMA1 (0.40) | MAPTGAAKMT2AMEN1CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |