Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | SELP | P16109 | 3/20 | 0.46 |
| ▸ | SELL | P14151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77742 | 0.89 | LMNA (0.65) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL9260618 | 0.86 | LMNA (0.70) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL11096445 | 0.80 | KMT2A (0.57) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL4878231 | 0.78 | HCAR2 (0.46) | KMT2AMEN1 | |
| SCHEMBL31001015 | 0.78 | KMT2A (0.52) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL11823849 | 0.77 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL30223686 | 0.77 | LMNA (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL1721306 | 0.77 | HTT (0.51) | LMNAKMT2AMEN1L3MBTL1SELP | |
| SCHEMBL19469640 | 0.77 | AKR1C3 (0.51) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL1465577 | 0.77 | LMNA (0.50) | LMNAKMT2AMEN1L3MBTL1SELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460604-A | ANALGESICS, NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1984-07-17 | — | — | US | disclosed |
| US-4180584-A | ANALGESIC; NARCOTIC ANTAGONIST | THE UPJOHN COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4065573-A | ANALGESICS | THE UPJOHN COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
| US-3979444-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, HYPOTENSIVES | THE UPJOHN COMPANY (US) | 1976-09-07 | — | — | US | disclosed |