Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 13/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11094339 | 0.82 | NPY5R (0.40) | NPY5RP2RY1NOTUMOPRM1OPRD1 | |
| SCHEMBL11085101 | 0.77 | AKT1 (0.49) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| Fumaric Acid SCHEMBL11095659 | 0.76 | P2RY1 (0.45) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| Maleic Acid SCHEMBL11095653 | 0.76 | P2RY1 (0.45) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| SCHEMBL11138166 | 0.76 | SLC18A3 (0.41) | SLC18A3SIGMAR1NPY5RP2RY1FFAR1 | |
| SCHEMBL11138170 | 0.76 | SLC18A3 (0.41) | SLC18A3SIGMAR1NPY5RP2RY1FFAR1 | |
| Bromide SCHEMBL11090547 | 0.76 | AKT1 (0.48) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| SCHEMBL11094372 | 0.76 | PDE4B (0.37) | — | |
| SCHEMBL11093235 | 0.74 | SLC18A3 (0.40) | SLC18A3SIGMAR1NPY5RP2RY1FFAR1 | |
| SCHEMBL11094423 | 0.73 | AKT1 (0.49) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4477667-A | Spiro[indoline-3,4'-piperidine]s and related compounds | AMERICAN HOECHST CORPORATION (US) | 1984-10-16 | — | — | US | disclosed |
| US-4408050-A | Spiro(indoline-3,4'-piperidine) and related compounds | AMERICAN HOECHST CORPORATION (US) | 1983-10-04 | — | — | US | disclosed |
| US-4379933-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| US-4307235-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |