Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.40 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11138170 | 1.00 | SLC18A3 (0.41) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| Maleic Acid SCHEMBL11095653 | 0.77 | P2RY1 (0.45) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| Fumaric Acid SCHEMBL11095659 | 0.77 | P2RY1 (0.45) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| SCHEMBL11139159 | 0.77 | PDE4B (0.38) | NPY5R | |
| SCHEMBL11139157 | 0.77 | PDE4B (0.38) | NPY5R | |
| SCHEMBL11095657 | 0.76 | SLC18A3 (0.43) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| SCHEMBL11085101 | 0.75 | AKT1 (0.49) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| Bromide SCHEMBL11090547 | 0.74 | AKT1 (0.48) | SLC18A3SIGMAR1NPY5RP2RY1NOTUM | |
| SCHEMBL11096094 | 0.73 | RIPK1 (0.49) | SIGMAR1NPY5RUSP2ALDH1A1HPGD | |
| Maleic Acid SCHEMBL11088205 | 0.73 | SIGMAR1 (0.72) | SLC18A3SIGMAR1USP2TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4345081-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1982-08-17 | — | — | US | claimed |
| US-4379932-A | Process for preparing spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1983-04-12 | — | — | US | disclosed |
| US-4209625-A | Spiro[indoline-3,4'-piperidine]s | AMERICAN HOECHST CORPORATION (US) | 1980-06-24 | — | — | US | disclosed |