Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.53 |
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19663896 | 0.82 | LMNA (0.50) | MDM2ESR1ESR2SMN1; SMN2BRD4 | |
| SCHEMBL3278733 | 0.76 | ESR1 (0.62) | MDM2ESR1ESR2KDM4EHPGD | |
| SCHEMBL17280128 | 0.74 | SMN1; SMN2 (0.50) | MDM2ESR1ESR2SMN1; SMN2BRD4 | |
| SCHEMBL28659479 | 0.74 | SMN1; SMN2 (0.73) | MDM2SMN1; SMN2BRD4CHEK1ALDH1A1 | |
| SCHEMBL25693651 | 0.71 | SMN1; SMN2 (0.47) | MDM2ESR1ESR2SMN1; SMN2BRD4 | |
| SCHEMBL9701635 | 0.70 | LMNA (0.50) | BRD4AKT2CHEK1PTGS2PDGFRA | |
| SCHEMBL5145616 | 0.70 | LMNA (0.50) | BRD4AKT2CHEK1PTGS2PDGFRA | |
| SCHEMBL19978177 | 0.70 | BRD4 (0.56) | MDM2SMN1; SMN2BRD4PTGS2 | |
| SCHEMBL6381138 | 0.68 | SMN1; SMN2 (0.49) | MDM2SMN1; SMN2BRD4KDM4EHPGD | |
| SCHEMBL8618279 | 0.68 | LMNA (0.48) | BRD4AKT2CHEK1PTGS2PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4477463-A | Antiinflammatory and/or analgesic 1-alkyl-4,5-diaryl-2-fluoroalkyl-1H-pyrroles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-10-16 | — | — | US | disclosed |
| US-4318917-A | PREPARED FROM A PYRROLE COMPOUND AND A 1-3-DITHIETANE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0044485-A1 | Antiinflammatory 2,3-diaryl-5(2,2,2-trifluoro-1-(trifluoromethyl)-ethyl)-1H-pyrroles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-01-27 | — | — | EP | disclosed |