Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 7/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233649 | 0.80 | HNF4A (0.69) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL11247108 | 0.77 | HNF4A (1.00) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL847484 | 0.77 | HNF4A (0.62) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL31279602 | 0.76 | HNF4A (1.00) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL11229865 | 0.76 | HNF4A (1.00) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL31237996 | 0.76 | HNF4A (1.00) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL27607138 | 0.76 | HNF4A (0.61) | HNF4APAX8TP53SMN1; SMN2KDM4E | |
| SCHEMBL16001173 | 0.74 | HNF4A (0.58) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL11093874 | 0.73 | HNF4A (0.60) | HNF4APAX8TP53CYP1A2BRCA1 | |
| SCHEMBL5026929 | 0.72 | HNF4A (0.57) | HNF4ATP53CYP1A2BRCA1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033702-B1 | 2-NITRONAPHTHOFURANE DERIVATIVES, THEIR PREPARATION AND THEIR USE, IN PARTICULAR AS CELL-GROWTH REGULATORS | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1984-01-04 | — | — | EP | claimed |
| US-4341794-A | ANIMAL GROWTH REGULATOR | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (FR) | 1982-07-27 | — | — | US | claimed |
| US-9981048-B2 | Methods for the treatment and prevention of liver disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981048-B2 | Methods for the treatment and prevention of liver disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-05-29 | — | — | US | disclosed |
| US-20140249209-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF LIVER DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140249209-A1 | METHODS FOR THE TREATMENT AND PREVENTION OF LIVER DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-09-04 | — | — | US | disclosed |
| US-4341794-A | ANIMAL GROWTH REGULATOR | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (FR) | 1982-07-27 | — | — | US | disclosed |
| US-4341794-A | ANIMAL GROWTH REGULATOR | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (FR) | 1982-07-27 | — | — | US | disclosed |
| EP-0033702-A2 | 2-Nitronaphthofurane derivatives, their preparation and their use, in particular as cell-growth regulators | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1981-08-12 | — | — | EP | disclosed |