Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CFTR | P13569 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11278666 | 0.98 | KDM4E (0.57) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL6492188 | 0.86 | ALDH1A1 (0.62) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL1027768 | 0.82 | ALDH1A1 (0.54) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL24391473 | 0.81 | MAPT (0.61) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL9541352 | 0.81 | ALDH1A1 (0.53) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL2847891 | 0.81 | MCL1 (0.47) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL10373447 | 0.81 | MCL1 (0.66) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL9770537 | 0.80 | MCL1 (0.50) | KDM4EGAAMAPTHSD17B10HPGD | |
| SCHEMBL3978328 | 0.80 | MCL1 (0.65) | KDM4EALDH1A1MAPTHSD17B10ALOX15 | |
| SCHEMBL10432256 | 0.80 | ALDH1A1 (0.51) | KDM4EALDH1A1GAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360085-A1 | Glucose Uptake Inhibitors | KADMON CORPORATION, LLC (US) | 2024-10-31 | — | — | US | disclosed |
| US-12030857-B2 | Glucose uptake inhibitors | KADMON CORPORATION, LLC (US) | 2024-07-09 | — | — | US | disclosed |
| US-20220363648-A1 | Glucose Uptake Inhibitors | KADMON CORPORATION, LLC | 2022-11-17 | — | — | US | disclosed |
| EP-0023594-B1 | TRANS-QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, INTERMEDIATES AND MEDICAMENTS CONTAINING THESE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-05-16 | — | — | EP | disclosed |
| US-4282360-A | ANTIALLERGENS | HOFFMANN-LA ROCHE INC. (US) | 1981-08-04 | — | — | US | disclosed |
| US-4281127-A | USEFUL AS ANTIALLERGENS | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030857-B2 | Glucose uptake inhibitors | SLC2A1, SLC2A4, SLC2A2 | KDM4E 2325/4885ALDH1A1 1422/4885GAA 332/4885 |
| US-20220363648-A1 | Glucose Uptake Inhibitors | SLC2A1, SLC2A4, SLC2A2 | KDM4E 2325/4885ALDH1A1 1422/4885GAA 332/4885 |
| US-20240360085-A1 | Glucose Uptake Inhibitors | SLC2A3, SLC2A1, SLC2A4 | KDM4E 2173/4885ALDH1A1 1565/4885GAA 343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.