Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10791780 | 0.79 | ADRB1 (0.56) | ADRB1ADRB2ADRB3CYP2D6MEN1 | |
| Hydrochloric Acid SCHEMBL10791060 | 0.78 | ADRB1 (0.56) | ADRB1ADRB2CYP2D6MEN1LMNA | |
| Hydrochloric Acid SCHEMBL10792419 | 0.77 | MAOB (0.37) | KDM4EFAAHMAOBMEN1KMT2A | |
| SCHEMBL10791408 | 0.77 | ADRB1 (0.56) | ADRB1ADRB2CYP2D6MEN1LMNA | |
| SCHEMBL9621528 | 0.76 | CYP1A2 (0.42) | KDM4EFAAHCYP2D6MEN1CYP1A2 | |
| SCHEMBL10793199 | 0.72 | ADRB2 (0.39) | ADRB1ADRB2ADRB3PPARAPPARG | |
| SCHEMBL10793210 | 0.72 | MAOB (0.46) | KDM4EMAOBMEN1LMNAKMT2A | |
| SCHEMBL4236119 | 0.71 | ADRB1 (0.52) | KDM4EADRB1ADRB2ADRB3CYP2D6 | |
| SCHEMBL10791453 | 0.69 | FFAR1 (0.48) | PPARDMAOBFFAR1 | |
| SCHEMBL875694 | 0.69 | ADRB1 (0.58) | ADRB1ADRB2CYP2D6MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041233-B1 | SUBSTITUTED PHENOXY-AMINOPROPANOL DERIVATIVES, INTERMEDIATES AND PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-15 | — | — | EP | claimed |