Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.47 |
| ▸ | RELA | Q04206 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12890455 | 0.82 | TSHR (0.54) | TSHRRAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL11099838 | 0.79 | RAB9A (0.38) | TSHRRAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL11101927 | 0.79 | RAB9A (0.49) | RAB9ASMN1; SMN2MAPTNPC1LMNA | |
| SCHEMBL4451648 | 0.78 | TSHR (0.49) | TSHRRAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL4451653 | 0.78 | TSHR (0.49) | TSHRRAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL9891915 | 0.77 | TSHR (0.66) | TSHRRAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL11255227 | 0.77 | RAB9A (0.40) | TSHRRAB9ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL11102318 | 0.75 | RAB9A (0.36) | TSHRRAB9ASMN1; SMN2MAPTPOLB | |
| SCHEMBL6700167 | 0.75 | TSHR (0.62) | TSHRRAB9ASMN1; SMN2KMT2AGAA | |
| SCHEMBL659214 | 0.74 | TSHR (0.71) | TSHRRAB9ASMN1; SMN2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042753-B1 | NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE | SYNTEX (U.S.A.) INC. (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4318905-A | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues | SYNTEX (U.S.A.) INC. (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0042753-A1 | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues, methods for their preparation, pharmaceutical compounds containing them, and their pharmaceutical use | SYNTEX (U.S.A.) INC. (US) | 1981-12-30 | — | — | EP | disclosed |