Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | CES1 | P23141 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732667 | 0.86 | CES2 (0.57) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5732673 | 0.84 | CES2 (0.51) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30758862 | 0.81 | CES2 (0.69) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11248287 | 0.81 | CES2 (0.69) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29588852 | 0.80 | CES2 (0.67) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1305114 | 0.80 | CES2 (0.67) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL733307 | 0.80 | CES2 (0.67) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11193938 | 0.79 | CES2 (0.61) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28009357 | 0.79 | CES2 (0.61) | CES2CES1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24262851 | 0.78 | CES2 (0.65) | CES2CES1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037713-B1 | NOVEL 1,3-DIHYDRO-1-((1-PIPERIDINYL)ALKYL)-2H-BENZIMIDAZOL-2-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-02-08 | — | — | EP | disclosed |
| EP-0037713-A1 | Novel 1,3-dihydro-1-((1-piperidinyl)alkyl)-2H-benzimidazol-2-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-14 | — | — | EP | disclosed |
| US-4254127-A | ANTIEMETIC, NEUROLIPTIC AND ANTICONGESTIVE AGENT | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-03-03 | — | — | US | disclosed |