Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.67 |
| ▸ | CES1 | P23141 | 1/20 | 0.67 |
| ▸ | PARP1 | P09874 | 1/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11248287 | 0.87 | CES2 (0.69) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL30758862 | 0.87 | CES2 (0.69) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL28228418 | 0.86 | MTNR1B (0.68) | NPC1RAB9ASMN1; SMN2POLBHPGD | |
| SCHEMBL4637827 | 0.86 | CES2 (0.62) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL28558306 | 0.85 | CTNNB1 (0.50) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL29588852 | 0.85 | CES2 (0.67) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL25736079 | 0.85 | ERCC5 (0.49) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL1305114 | 0.85 | CES2 (0.67) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL24262851 | 0.84 | CES2 (0.65) | CES2CES1PARP1HDAC3HDAC4 | |
| SCHEMBL13780501 | 0.84 | CES2 (0.65) | CES2CES1PARP1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 403 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114858944-B | Method for detecting p-methoxypropiophenone related substances | 石家庄四药有限公司 | 2023-02-03 | — | — | CN | claimed |
| EP-4116288-A1 | RACEMIZATION OF (S) AND/OR (R)-3-(DIMETHYLAMINO)-1-(3-METHOXYPHENYL)-2-METHYLPROPAN-1- ONE AND ITS MIXTURES | KRKA, d.d., Novo mesto (SI) | 2023-01-11 | — | — | EP | claimed |
| CN-114858944-A | Method for detecting p-methoxypropiophenone related substances | 石家庄四药有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-114733471-A | Tubular reactor suitable for producing m-methoxypropiophenone | 东营曜康医药科技有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-112255357-B | Analysis method for qualitative determination of unknown impurities in m-methoxypropiophenone process by gas chromatography-mass spectrometry | 济南悟通生物科技有限公司 | 2021-12-03 | — | — | CN | claimed |
| CN-112255357-A | Analysis method for qualitative determination of unknown impurities in m-methoxypropiophenone process by gas chromatography-mass spectrometry | 济南悟通生物科技有限公司 | 2021-01-22 | — | — | CN | claimed |
| EP-3713911-A1 | METHOD FOR THE PREPARATION OF TAPENTADOL AND ITS INTERMEDIATES | Saneca Pharmaceuticals a.s. (SK) | 2020-09-30 | — | — | EP | claimed |
| CN-108083999-B | Green preparation method of alpha-hydroxyketone | 西北师范大学 | 2020-08-11 | — | — | CN | claimed |
| CN-210846394-U | Tubular reactor suitable for producing m-methoxypropiophenone | 济南悟通生物科技有限公司 | 2020-06-26 | — | — | CN | claimed |
| CN-210141720-U | Device for preventing condenser from being blocked by ice in synthesis of m-methoxy propiophenone | 东营曜康医药科技有限公司 | 2020-03-13 | — | — | CN | claimed |
| WO-2019035775-A1 | METHOD FOR THE PREPARATION OF TAPENTADOL AND ITS INTERMEDIATES | SANECA PHARMACEUTICALS A.S. (SK) | 2019-02-21 | — | — | WO | claimed |
| EP-2519100-B1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA LTD (IL) | 2017-03-15 | — | — | EP | claimed |
| CN-106278915-A | A kind of method preparing tapentadol hydrochloride intermediate | 重庆圣华曦药业股份有限公司 | 2017-01-04 | — | — | CN | claimed |
| CN-104355981-A | Preparation method of tapentadol intermediate methoxypropiophenone | SUZHOU JONATHAN NEW MATERIALS TECHNOLOGY CO LTD | 2015-02-18 | — | — | CN | claimed |
| CN-101671245-B | Process for preparing 3-methoxypropiophenone | TANG BAOQING | 2014-07-09 | — | — | CN | claimed |
| US-8410176-B2 | Intermediate compounds and processes for the preparation of tapentadol and related compounds | MAPI PHARMA LTD. (IL) | 2013-04-02 | — | — | US | claimed |
| US-20120283463-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA LIMITED (IL) | 2012-11-08 | — | — | US | claimed |
| CN-101671245-A | Process for preparing 3-methoxypropiophenone | BAOQING TANG | 2010-03-17 | — | — | CN | claimed |
| EP-3210965-B2 | PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL | GRUENENTHAL GMBH (DE) | 2026-05-13 | — | — | EP | disclosed |
| US-4147872-A | 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor | PFIZER INC. (US) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283463-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | PNMT, OPRK1, CYP2E1 | CES2 324/4885CES1 303/4885PARP1 3517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.