SCHEMBL11097665

SCHEMBL11097665

NN=C(C(=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.60
CES1 P23141 3/20 0.60
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.45
LMNA P02545 2/20 0.45
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.43
FLT1 P17948 1/20 0.43
FLT4 P35916 1/20 0.43
KDR P35968 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
GSK3B P49841 2/20 0.42
SRD5A2 P31213 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10981500 0.79 CES2 (0.60) CES2CES1CA1CA2SMN1; SMN2
SCHEMBL7790426 0.78 CES2 (0.56) CES2CES1TSHRL3MBTL1LMNA
SCHEMBL17485943 0.78 CES2 (0.56) CES2CES1TSHRL3MBTL1LMNA
SCHEMBL10131971 0.78 CES2 (0.58) CES2CES1ALOX15TSHRL3MBTL1
SCHEMBL10131977 0.78 CES2 (0.58) CES2CES1ALOX15TSHRL3MBTL1
SCHEMBL273857 0.77 CES2 (1.00) CES2CES1ALOX15TSHRL3MBTL1
SCHEMBL7929793 0.75 CES2 (0.50) CES2CES1LMNASMN1; SMN2NPC1
SCHEMBL10818628 0.73 CES2 (0.47) CES2CES1ALOX15TSHRL3MBTL1
SCHEMBL3658715 0.73 CES2 (0.71) CES2CES1ALOX15TSHRL3MBTL1
SCHEMBL29025701 0.72 CES2 (0.79) CES2CES1ALOX15TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4286091-A CYCLIZATION OF A CORRESPONDING HYDRAZONE DIAMOND SHAMROCK CORPORATION (US) 1981-08-25 US claimed
US-4281125-A CYCLIZATION DIAMOND SHAMROCK CORPORATION (US) 1981-07-28 US claimed
EP-0088128-A4 ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES. DIAMOND SHAMROCK CORP (US) 1984-04-06 EP disclosed
EP-0088128-A1 ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES DIAMOND SHAMROCK CORPORATION (US) 1983-09-14 EP disclosed
WO-1983000863-A1 ANTIINFLAMMATORY AND ANALGETIC 4-PYRIDYLPYRIDAZIN(2H)-3-ONES DIAMOND SHAMROCK CORP (US) 1983-03-17 WO disclosed
EP-0018063-B1 PYRIDAZIN (2H)-3-ONES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN ANTIHYPERTENSIVE AGENTS DIAMOND SHAMROCK CORPORATION (US) 1983-02-23 EP disclosed
US-4286091-A CYCLIZATION OF A CORRESPONDING HYDRAZONE DIAMOND SHAMROCK CORPORATION (US) 1981-08-25 US disclosed
US-4286091-A CYCLIZATION OF A CORRESPONDING HYDRAZONE DIAMOND SHAMROCK CORPORATION (US) 1981-08-25 US disclosed
US-4281125-A CYCLIZATION DIAMOND SHAMROCK CORPORATION (US) 1981-07-28 US disclosed
US-4281125-A CYCLIZATION DIAMOND SHAMROCK CORPORATION (US) 1981-07-28 US disclosed
EP-0018063-A1 Pyridazin (2H)-3-ones, process for their preparation and their use in antihypertensive agents DIAMOND SHAMROCK CORPORATION (US) 1980-10-29 EP disclosed