Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | GRIA1 | P42261 | 7/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 7/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 7/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11096920 | 0.90 | LMNA (0.62) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL11100296 | 0.83 | MEN1 (0.66) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL11099056 | 0.81 | LMNA (0.62) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL29701185 | 0.79 | CYP1A2 (1.00) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL612079 | 0.79 | CYP1A2 (1.00) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL11506711 | 0.74 | MEN1 (0.57) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL11506715 | 0.73 | LMNA (0.56) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL15730579 | 0.73 | GRIA1 (0.68) | MEN1LMNACYP1A2TSHRBLM | |
| SCHEMBL30546561 | 0.72 | LMNA (0.64) | MEN1LMNACYP1A2TSHRKMT2A | |
| SCHEMBL7143500 | 0.72 | LMNA (0.64) | MEN1LMNACYP1A2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037713-B1 | NOVEL 1,3-DIHYDRO-1-((1-PIPERIDINYL)ALKYL)-2H-BENZIMIDAZOL-2-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-02-08 | — | — | EP | disclosed |
| US-4254127-A | ANTIEMETIC, NEUROLIPTIC AND ANTICONGESTIVE AGENT | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-03-03 | — | — | US | disclosed |