Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11166001 | 0.89 | ALDH1A1 (0.57) | ALDH1A1TP53SMN1; SMN2MAPTHPGD | |
| SCHEMBL11166790 | 0.86 | ALDH1A1 (0.49) | NR1H2NR1H3ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL11098913 | 0.83 | CCR2 (0.50) | NR1H2NR1H3SIGMAR1ALDH1A1TP53 | |
| SCHEMBL10854740 | 0.80 | BCL2 (0.39) | ALDH1A1TP53SMN1; SMN2MAPTHPGD | |
| SCHEMBL11096714 | 0.78 | ALDH1A1 (0.57) | ALDH1A1TP53SMN1; SMN2MAPTHPGD | |
| SCHEMBL11095317 | 0.78 | TSHR (0.52) | ALDH1A1SMN1; SMN2MAPTHPGDUSP2 | |
| SCHEMBL11093981 | 0.77 | TLR7 (0.49) | NR1H2NR1H3ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL11098723 | 0.76 | CASR (0.47) | ALDH1A1TP53SMN1; SMN2HPGDKMT2A | |
| SCHEMBL11094576 | 0.74 | ALDH1A1 (0.40) | ALDH1A1TP53MAPTHPGDHTT | |
| SCHEMBL5331858 | 0.74 | AR (0.48) | ALDH1A1MAPTHPGDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028834-B1 | IMIDAZOLE-5-ACETIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-18 | — | — | EP | disclosed |
| US-4355040-A | Hypotensive imidazole-5-acetic acid derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-10-19 | — | — | US | disclosed |