Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 5/20 | 0.46 |
| ▸ | BUB1 | O43683 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11101947 | 0.87 | NOS2 (0.54) | MAPK14MKNK2MAPK13MAPK12MAPK11 | |
| SCHEMBL11100061 | 0.82 | MAPK14 (0.48) | MAPK14MKNK1MKNK2HTR7MAPK13 | |
| SCHEMBL11102704 | 0.81 | HRH4 (0.41) | MAPK14MKNK1MKNK2CDK2HRH4 | |
| SCHEMBL1502132 | 0.78 | PRKD1 (0.44) | MAPK14MAPK13MAPK12MAPK11HRH4 | |
| SCHEMBL11101105 | 0.77 | MAPK14 (0.50) | MAPK14HTR7TAAR1HRH4 | |
| SCHEMBL25095006 | 0.73 | MAPK10 (0.33) | MAPK14 | |
| SCHEMBL11102425 | 0.73 | ROCK1 (0.44) | BUB1CCNA2CDK2 | |
| SCHEMBL31240809 | 0.72 | CCNC (0.58) | MKNK1MKNK2HTR7ACHEMEN1 | |
| SCHEMBL28043558 | 0.72 | CCNC (0.58) | MAPK14MKNK1MKNK2HTR7ACHE | |
| SCHEMBL11100755 | 0.72 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0051371-B1 | IMIDAZOLYLPYRIDINE THERAPEUTIC AGENTS | PFIZER INC. (US) | 1984-08-29 | — | — | EP | disclosed |
| EP-0051371-A2 | Imidazolylpyridine therapeutic agents | PFIZER INC. (US) | 1982-05-12 | — | — | EP | disclosed |
| US-4302464-A | ANTIULCER AGENTS, ANTI-H2-HISTAMINES | PFIZER INC. (US) | 1981-11-24 | — | — | US | disclosed |