Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.44 |
| ▸ | MERTK | Q12866 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949550 | 0.90 | MAPK1 (0.48) | MAPK8MAPK10MAPK9MAPK1HDAC3 | |
| SCHEMBL24756044 | 0.83 | MKNK1 (0.40) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL30136596 | 0.83 | MKNK1 (0.40) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL16039970 | 0.81 | MAPK8 (0.49) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL16039969 | 0.81 | MAPK8 (0.49) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL29761508 | 0.80 | MAPK8 (0.55) | MAPK8MAPK10MAPK9FLT3HDAC3 | |
| SCHEMBL17730228 | 0.79 | KDM4E (0.64) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL17730226 | 0.79 | KDM4E (0.64) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL26813998 | 0.79 | KDM4E (0.64) | MAPK8MAPK10MAPK9MAPK1TYRO3 | |
| SCHEMBL11100732 | 0.78 | MAPK8 (0.50) | MAPK8MAPK10MAPK9TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021176-B1 | CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-01-18 | — | — | EP | disclosed |
| US-4388315-A | TAUTOMERIC PYRIMIDINE DERIVATIVES | BOEHRINGER INGELEHEIM GMBH (DE) | 1983-06-14 | — | — | US | disclosed |
| EP-0021176-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1981-01-07 | — | — | EP | disclosed |