Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24756044 | 1.00 | MKNK1 (0.40) | MKNK1MKNK2MAPK8MAPK1HDAC3 | |
| SCHEMBL11099362 | 0.83 | MAPK8 (0.49) | MAPK8MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL2949550 | 0.79 | MAPK1 (0.48) | MAPK8MAPK1HDAC3HDAC1HDAC2 | |
| SCHEMBL26675787 | 0.77 | HCAR3 (0.42) | MKNK1MKNK2TYRO3MERTK | |
| SCHEMBL26675753 | 0.77 | HCAR3 (0.42) | MKNK1MKNK2TYRO3MERTK | |
| SCHEMBL30716711 | 0.77 | HCAR3 (0.42) | MKNK1MKNK2TYRO3MERTK | |
| SCHEMBL26675750 | 0.77 | HCAR3 (0.42) | MKNK1MKNK2TYRO3MERTK | |
| SCHEMBL24655823 | 0.74 | HRH3 (0.46) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30136658 | 0.74 | GSK3A (0.41) | MKNK1MKNK2MAPK8MAPK1HDAC3 | |
| SCHEMBL23500917 | 0.70 | ENPP2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813293-A | Urea derivatives useful for the treatment of cancer | 蝎子疗法股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-4334298-A1 | UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER | Scorpion Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022265993-A1 | UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER | SCORPION THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |