Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 10/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.48 |
| ▸ | GSK3A | P49840 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998071 | 0.94 | MAPK8 (0.41) | MAPK8MAPK10MAPK9 | |
| SCHEMBL10996398 | 0.87 | ULK1 (0.48) | MAPK8MAPK9AXLFLT3TYRO3 | |
| SCHEMBL11000513 | 0.87 | PAK1 (0.47) | MAPK8MAPK9ADORA1AXLFLT3 | |
| SCHEMBL11002130 | 0.86 | GRM5 (0.49) | MAPK8MAPK10MAPK9JUNFLT3 | |
| SCHEMBL10999501 | 0.86 | PAK1 (0.49) | MAPK8AXLFLT3TYRO3MERTK | |
| SCHEMBL10998140 | 0.86 | PAK1 (0.49) | MAPK8AXLFLT3TYRO3MERTK | |
| SCHEMBL384642 | 0.81 | MAPK8 (0.58) | MAPK8MAPK10MAPK9GSK3AGSK3B | |
| SCHEMBL384641 | 0.81 | MAPK8 (0.58) | MAPK8MAPK10MAPK9GSK3AGSK3B | |
| SCHEMBL11099362 | 0.78 | MAPK8 (0.49) | MAPK8MAPK10MAPK9GSK3AGSK3B | |
| SCHEMBL14671138 | 0.76 | MAPK8 (0.50) | MAPK8MAPK10MAPK9GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021176-B1 | CEPHALOSPORIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-01-18 | — | — | EP | disclosed |
| EP-0035161-B1 | CEPHALOSPORINS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1983-11-23 | — | — | EP | disclosed |
| US-4388315-A | TAUTOMERIC PYRIMIDINE DERIVATIVES | BOEHRINGER INGELEHEIM GMBH (DE) | 1983-06-14 | — | — | US | disclosed |
| US-4370327-A | Cephalosporins and pharmaceutical compositions | BOEHRINGER INGELHEIM GMBH (DE) | 1983-01-25 | — | — | US | disclosed |
| EP-0016374-B1 | PENICILLINS, THEIR SALTS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1982-03-03 | — | — | EP | disclosed |
| US-4316898-A | AS ANTIBIOTICS | BOEHRINGER INGELHEIM KG (DE) | 1982-02-23 | — | — | US | disclosed |
| EP-0044992-A1 | Lactams, process for their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1982-02-03 | — | — | EP | disclosed |
| US-4289775-A | BACTERICIDAL ANTIBIOTICS | KARL THOMAE GMBH (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0035161-A2 | Cephalosporins, processes for their preparation and pharmaceutical compositions containing these compounds | Dr. Karl Thomae GmbH (DE) | 1981-09-09 | — | — | EP | disclosed |
| EP-0021176-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1981-01-07 | — | — | EP | disclosed |
| EP-0016374-A1 | Penicillins, their salts, process for their preparation and therapeutic agents containing these compounds | Dr. Karl Thomae GmbH (DE) | 1980-10-01 | — | — | EP | disclosed |