Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099312 | 0.93 | MAOB (0.38) | MAOBTUBB1HPGDLMNATP53 | |
| Tolmesoxide SCHEMBL2109962 | 0.84 | ACHE (0.37) | CYP3A4MEN1RAB9AKMT2AALDH1A1 | |
| SCHEMBL11141284 | 0.75 | TUBB1 (0.50) | MAOBTUBB1HPGDTP53CYP3A4 | |
| SCHEMBL70697 | 0.73 | CYP3A4 (0.50) | MAOBTUBB1HPGDLMNATP53 | |
| SCHEMBL14340764 | 0.73 | MAOB (0.48) | MAOBTUBB1HPGDTP53CYP3A4 | |
| SCHEMBL11100863 | 0.72 | CYP3A4 (0.37) | MAOBHPGDCYP3A4MEN1RAB9A | |
| SCHEMBL69624 | 0.70 | MAOB (0.59) | MAOBHPGDLMNATP53CYP3A4 | |
| SCHEMBL11154406 | 0.69 | ALOX15 (0.55) | MAOBHPGDLMNATP53CYP3A4 | |
| SCHEMBL3674401 | 0.69 | MAOB (0.48) | MAOBTUBB1HPGDLMNATP53 | |
| SCHEMBL29421892 | 0.69 | MAOB (0.48) | MAOBTUBB1HPGDLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0043736-B1 | PROPANOLAMINE DERIVATIVES, THEIR SALTS, PROCESSES FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1984-04-25 | — | — | EP | disclosed |
| US-4410548-A | HYPOTENSIVE AGENTS | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1983-10-18 | — | — | US | disclosed |
| EP-0043736-A1 | Propanolamine derivatives, their salts, processes for preparation and pharmaceutical compositions | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1982-01-13 | — | — | EP | disclosed |