Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 17/20 | 0.66 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.60 |
| ▸ | PARP15 | Q460N3 | 6/20 | 0.59 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.59 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.59 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10506137 | 0.89 | MEN1 (0.58) | PARP10ALDH1A1KMT2APOLBBLM | |
| SCHEMBL6538687 | 0.86 | PLA2G4B (0.61) | PARP10PARP15POLBBLMTDP1 | |
| SCHEMBL1532777 | 0.86 | PARP10 (0.65) | PARP10AOC3PARP15PARP4ALDH1A1 | |
| SCHEMBL11099688 | 0.84 | PARP10 (0.61) | PARP10AOC3PARP15PARP4ALDH1A1 | |
| SCHEMBL13065104 | 0.84 | L3MBTL1 (0.63) | PARP10ALDH1A1MAOBPOLBBLM | |
| SCHEMBL10753741 | 0.84 | PARP10 (0.67) | PARP10AOC3PARP15PARP4ALDH1A1 | |
| SCHEMBL1756119 | 0.82 | SMN1; SMN2 (0.68) | PARP10ALDH1A1KMT2APOLBBLM | |
| SCHEMBL24687938 | 0.81 | GAA (0.62) | PARP10ALDH1A1KMT2A | |
| SCHEMBL8770195 | 0.81 | POLB (0.70) | PARP10AOC3PARP15PARP4ALDH1A1 | |
| SCHEMBL6538707 | 0.81 | MAPT (0.68) | KMT2ACA1CA2POLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507243-B1 | SPIROINDOLINONE PYRROLIDINES | HOFFMANN LA ROCHE (CH) | 2015-06-10 | — | — | EP | claimed |
| EP-2507243-A1 | SPIROINDOLINONE PYRROLIDINES | F. Hoffmann-La Roche AG (CH) | 2012-10-10 | — | — | EP | claimed |
| EP-2507243-B1 | SPIROINDOLINONE PYRROLIDINES | HOFFMANN LA ROCHE (CH) | 2015-06-10 | — | — | EP | disclosed |
| EP-2507243-A1 | SPIROINDOLINONE PYRROLIDINES | F. Hoffmann-La Roche AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| EP-0014567-B1 | PROCESSES FOR PREPARATION OF BETA-LACTAM COMPOUNDS | ELI LILLY AND COMPANY (US) | 1984-01-18 | — | — | EP | disclosed |
| US-4271305-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1981-06-02 | — | — | US | disclosed |
| US-4226986-A | 7-ACYLAMINO-3-HYDROXY-3-CEPHEM COMPOUND, TRIARYL PHOSPHITE DIHALIDE | ELI LILLY AND COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-4223133-A | USING A TRIARYL PHOSPHITE-HALOGEN COMPLEX | ELI LILLY AND COMPANY (US) | 1980-09-16 | — | — | US | disclosed |
| EP-0014567-A1 | Processes for preparation of beta-lactam compounds | ELI LILLY AND COMPANY (US) | 1980-08-20 | — | — | EP | disclosed |
| US-4211702-A | TRIARYLPHOSPHITE-HALOGEN COMPLEX HALOGENATING AGENT | ELI LILLY AND COMPANY (US) | 1980-07-08 | — | — | US | disclosed |