Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17527284 | 0.91 | BCHE (0.55) | ADRB2OPRK1ADRB1LMNAMEN1 | |
| SCHEMBL8906047 | 0.88 | ADRB3 (0.60) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL8906311 | 0.88 | ADRB2 (0.55) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL8904588 | 0.87 | OPRK1 (0.57) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL8904970 | 0.87 | OPRK1 (0.57) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL9590684 | 0.86 | ADRB2 (0.76) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL8907024 | 0.86 | OPRK1 (0.56) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL11102216 | 0.85 | MEN1 (0.59) | ADRB2OPRK1ADRB1LMNAALDH1A1 | |
| SCHEMBL23022855 | 0.84 | BCHE (0.52) | ADRB2LMNAALDH1A1HIF1AMEN1 | |
| SCHEMBL1438054 | 0.84 | BCHE (0.55) | ADRB2OPRK1DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040956-B1 | 8-SUBSTITUTED 4-(3,4-DIHYDROXYPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINES | SMITHKLINE BECKMAN CORPORATION (US) | 1984-10-31 | — | — | EP | disclosed |
| US-4340600-A | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines | SMITHKLINE CORPORATION (US) | 1982-07-20 | — | — | US | disclosed |
| EP-0040956-A1 | 8-Substituted 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines | SMITHKLINE BECKMAN CORPORATION (US) | 1981-12-02 | — | — | EP | disclosed |