Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.59 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099638 | 0.76 | PDE3B (0.59) | PDE3BPDE3APDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL11102712 | 0.75 | PDE3B (0.58) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11094601 | 0.75 | CYP3A4 (0.56) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11099239 | 0.74 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL2533488 | 0.71 | TSHR (0.84) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL2532397 | 0.69 | LMNA (0.78) | TSHRMEN1ALOX15KMT2ACYP3A4 | |
| SCHEMBL11098328 | 0.68 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL696731 | 0.68 | LMNA (0.64) | TSHRMEN1ALOX15KMT2ACYP3A4 | |
| Hydrochloric Acid SCHEMBL28701756 | 0.67 | LMNA (0.75) | TSHRMEN1ALOX15KMT2ACYP3A4 | |
| SCHEMBL19186987 | 0.67 | KMT2A (0.70) | PDE3BPDE3ATSHRMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |