Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3060808 | 0.93 | KDM4E (0.42) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| Bromide SCHEMBL10913183 | 0.92 | KDM4E (0.41) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL7277003 | 0.86 | HSD17B1 (0.42) | KDM4EMAPTALDH1A1POLBBLM | |
| SCHEMBL16605573 | 0.84 | KDM4E (0.40) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL24803566 | 0.81 | KDM4E (0.38) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL30758546 | 0.81 | KDM4E (0.38) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL29511535 | 0.81 | PARP1 (0.39) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL199421 | 0.81 | PARP1 (0.39) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL268919 | 0.81 | PARP1 (0.39) | KDM4EMAPTALDH1A1CYP2C19POLB | |
| SCHEMBL29410824 | 0.81 | PARP1 (0.39) | KDM4EMAPTALDH1A1CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035339-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | ATRANSEN PHARMA LTD (JP) | 2026-02-05 | — | — | US | disclosed |
| EP-4501906-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | Atransen Pharma Ltd. (JP) | 2025-02-05 | — | — | EP | disclosed |
| CN-118974007-A | Tetrahydronaphthalene derivatives | 阿创森制药股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023190878-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | Ａｔｒａｎｓｅｎ Ｐｈａｒｍａ株式会社 | 2023-10-05 | — | — | WO | disclosed |
| WO-2023190878-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | Ａｔｒａｎｓｅｎ Ｐｈａｒｍａ株式会社 | 2023-10-05 | — | — | WO | disclosed |
| US-4438103-A | ANALGESIC OLIGOPEPTIDES | SANDOZ LTD. (CH) | 1984-03-20 | — | — | US | disclosed |
| US-4261888-A | ANALGESIC OLIGOPEPTIDES | SANDOZ LTD. (CH) | 1981-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260035339-A1 | TETRAHYDRONAPHTHALENE DERIVATIVE | LATS1, LATS2, BCAT1 | KDM4E 3452/4885MAPT 905/4885ALDH1A1 1267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.