Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPRA | P18433 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099435 | 0.87 | MEN1 (0.50) | KMOCYP1A2CYP3A4CYP2C9MEN1 | |
| SCHEMBL11096618 | 0.86 | AKR1B1 (0.46) | CYP1A2CYP3A4PTPRAPTPRBPKM | |
| SCHEMBL11105224 | 0.85 | KDM4E (0.43) | PTPRAPTPRBPKMMAPTAKR1B1 | |
| SCHEMBL11102891 | 0.82 | PTPRA (0.39) | KMOPTPRAPTPRBPKM | |
| SCHEMBL11098155 | 0.77 | GRIA1 (0.43) | CYP1A2CYP3A4CYP2C9MEN1KMT2A | |
| SCHEMBL11100833 | 0.74 | GAA (0.45) | CYP1A2CYP3A4MEN1KMT2APTPRA | |
| SCHEMBL11099516 | 0.73 | NPC1 (0.53) | MEN1KMT2APTPRAPTPRBPKM | |
| SCHEMBL1627274 | 0.73 | NPC1 (0.53) | MEN1KMT2APTPRAPTPRBPKM | |
| SCHEMBL5288034 | 0.73 | NPC1 (0.53) | MEN1KMT2APTPRAPTPRBPKM | |
| SCHEMBL11255199 | 0.73 | FFAR2 (0.46) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042753-B1 | NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE | SYNTEX (U.S.A.) INC. (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4318905-A | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues | SYNTEX (U.S.A.) INC. (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0042753-A1 | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues, methods for their preparation, pharmaceutical compounds containing them, and their pharmaceutical use | SYNTEX (U.S.A.) INC. (US) | 1981-12-30 | — | — | EP | disclosed |