Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | MTR | Q99707 | 1/20 | 0.47 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11108153 | 0.91 | CTSS (0.51) | CHRM4CALCRLCHRM1RAMP1CTSS | |
| SCHEMBL11103893 | 0.89 | CTSS (0.51) | CHRM4CALCRLCHRM1RAMP1CTSS | |
| SCHEMBL11099726 | 0.89 | SCN1A (0.55) | CHRM4CALCRLCHRM1SCN1ASCN5A | |
| SCHEMBL11105185 | 0.87 | CTSS (0.57) | CHRM4CALCRLCHRM1RAMP1CTSS | |
| SCHEMBL11099237 | 0.84 | CTSS (0.43) | CHRM4CALCRLCHRM1RAMP1CTSS | |
| SCHEMBL11102366 | 0.84 | SCN1A (0.50) | CHRM4CALCRLCHRM1SCN1ASCN5A | |
| SCHEMBL11105849 | 0.84 | SCN1A (0.48) | CHRM4CALCRLCHRM1SCN1ASCN5A | |
| SCHEMBL27752167 | 0.81 | CHRM4 (0.57) | CHRM4CALCRLCHRM1RAMP1 | |
| SCHEMBL9046543 | 0.80 | CHRM4 (0.70) | CHRM4CALCRLRAMP1CTSS | |
| SCHEMBL14098799 | 0.79 | CHRM4 (0.56) | CHRM4CALCRLCHRM1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4344948-A | HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |