Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CALCRL | Q16602 | 5/20 | 0.41 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11104912 | 0.85 | LMNA (0.39) | CTSSLMNAMAPK1ALDH1A1TSHR | |
| SCHEMBL11108061 | 0.84 | LMNA (0.43) | LMNAMAPK1ALDH1A1TSHROPRM1 | |
| SCHEMBL11101376 | 0.84 | CHRM4 (0.52) | CTSSCHRM4CHRM1CALCRLRAMP1 | |
| SCHEMBL11105185 | 0.84 | CTSS (0.57) | CTSSCHRM4CHRM1CALCRLRAMP1 | |
| SCHEMBL11108153 | 0.82 | CTSS (0.51) | CTSSCHRM4TSHRCHRM1CALCRL | |
| SCHEMBL11103893 | 0.82 | CTSS (0.51) | CTSSCHRM4CHRM1CALCRLRAMP1 | |
| SCHEMBL11102366 | 0.81 | SCN1A (0.50) | CTSSCHRM4CHRM1CALCRL | |
| SCHEMBL11104105 | 0.80 | MAOB (0.53) | CTSSLMNACHRM4MAPK1ALDH1A1 | |
| SCHEMBL11099726 | 0.80 | SCN1A (0.55) | CTSSCHRM4CHRM1CALCRL | |
| SCHEMBL11267525 | 0.79 | LMNA (0.46) | CTSSLMNAMAPK1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4344948-A | HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |