Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.48 |
| ▸ | NMUR2 | Q9GZQ4 | 2/20 | 0.43 |
| ▸ | NMUR1 | Q9HB89 | 2/20 | 0.43 |
| ▸ | NPY4R | P50391 | 3/20 | 0.43 |
| ▸ | NPY1R | P25929 | 2/20 | 0.43 |
| ▸ | NPY2R | P49146 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | RAMP3 | O60896 | 3/20 | 0.42 |
| ▸ | CALCR | P30988 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11101528 | 1.00 | OPRK1 (0.48) | OPRK1OPRM1NMUR2NMUR1NPY4R | |
| SCHEMBL31481586 | 0.94 | OPRK1 (0.47) | OPRK1OPRM1NMUR2NMUR1NPY4R | |
| SCHEMBL30689268 | 0.91 | OPRK1 (0.58) | OPRK1OPRM1NMUR2NMUR1NPY4R | |
| SCHEMBL29421084 | 0.91 | OPRM1 (0.52) | OPRK1OPRM1NMUR2NMUR1RAMP3 | |
| SCHEMBL11644393 | 0.91 | OPRK1 (0.43) | OPRK1OPRM1NPY4RNPY1RNPY2R | |
| SCHEMBL9616907 | 0.91 | OPRK1 (0.43) | OPRK1OPRM1NPY4RNPY1RNPY2R | |
| SCHEMBL9616909 | 0.91 | OPRK1 (0.43) | OPRK1OPRM1NPY4RNPY1RNPY2R | |
| SCHEMBL31070376 | 0.90 | CAPN1 (0.50) | OPRK1OPRM1NMUR2NMUR1 | |
| SCHEMBL31437168 | 0.89 | RAMP3 (0.47) | OPRK1OPRM1NMUR2NMUR1RAMP3 | |
| SCHEMBL29813882 | 0.88 | OPRK1 (0.44) | OPRK1OPRM1NMUR2NMUR1NPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042753-B1 | NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE | SYNTEX (U.S.A.) INC. (US) | 1984-03-21 | — | — | EP | disclosed |