Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11092367 | 0.84 | SIGMAR1 (0.61) | SIGMAR1HTR1A | |
| SCHEMBL7846425 | 0.83 | SIGMAR1 (0.65) | SIGMAR1HTR1ADRD3CHRM2CHRM3 | |
| SCHEMBL11102692 | 0.83 | DRD1 (0.62) | DRD3DRD4DRD2 | |
| SCHEMBL7511173 | 0.75 | MAOA (0.59) | DRD3DRD4DRD2 | |
| SCHEMBL1588555 | 0.72 | SIGMAR1 (0.63) | SIGMAR1HTR1ADRD3CHRM2CHRM3 | |
| SCHEMBL15144639 | 0.72 | SIGMAR1 (0.60) | SIGMAR1 | |
| SCHEMBL28217942 | 0.72 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL3693352 | 0.72 | SIGMAR1 (0.75) | SIGMAR1HTR1ADRD3CHRM2CHRM3 | |
| SCHEMBL1960380 | 0.72 | SIGMAR1 (0.71) | SIGMAR1HTR1ADRD4HDAC1HDAC6 | |
| SCHEMBL10673708 | 0.72 | TMEM97 (0.78) | SIGMAR1HTR1ADRD3CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057777-B1 | DIBENZOXAZONINE, DIBENZOXAZECINE, DIBENZOXAAZACYCLOUNDECANE DERIVATIVES AND THEIR CORRESPONDING THIA- AND AZA DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-10 | — | — | EP | disclosed |
| US-4374133-A | PSYCHOLOGICAL DISORDERS | AKZO N.V. (NL) | 1983-02-15 | — | — | US | disclosed |