Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CALCRL | Q16602 | 6/20 | 0.44 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11102417 | 1.00 | MAPK1 (0.48) | MAPK1CALCRLRAMP1NAMPTGPR119 | |
| SCHEMBL2604336 | 0.84 | CALCRL (0.58) | MAPK1CALCRLRAMP1NAMPTCHRM4 | |
| SCHEMBL14498121 | 0.78 | HTR2C (0.41) | CALCRL | |
| SCHEMBL14410233 | 0.77 | PARP1 (0.40) | CALCRLRAMP1 | |
| Hydrochloric Acid SCHEMBL11097882 | 0.77 | HTR2C (0.40) | CALCRL | |
| Hydrochloric Acid SCHEMBL11160630 | 0.77 | HTR2C (0.40) | CALCRL | |
| SCHEMBL1820339 | 0.77 | CALCRL (0.50) | MAPK1CALCRLRAMP1NAMPTGPR119 | |
| SCHEMBL5369548 | 0.76 | BRD4 (0.33) | CALCRL | |
| SCHEMBL12372577 | 0.75 | MAPK1 (0.47) | MAPK1CALCRLRAMP1NAMPTGPR119 | |
| SCHEMBL12511957 | 0.73 | NAMPT (0.53) | MAPK1NAMPTGPR119PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4410528-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |