Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.56 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8141575 | 0.86 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL8150231 | 0.86 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL13153611 | 0.83 | CYP2A6 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL148642 | 0.83 | CYP2A6 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL17849089 | 0.83 | CYP2A6 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL23312077 | 0.83 | CYP2A6 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL17849092 | 0.83 | CYP2A6 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL29427549 | 0.83 | CYP2A6 (0.68) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL29353067 | 0.83 | CYP2A6 (0.77) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL192166 | 0.83 | CYP2A6 (0.77) | ALDH1A1KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042753-B1 | NONAPEPTIDE AND DECAPEPTIDE AGONISTS OF LUTEINIZING HORMONE RELEASING HORMONE CONTAINING HETEROCYCLIC AMINO ACID RESIDUES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM, AND THEIR PHARMACEUTICAL USE | SYNTEX (U.S.A.) INC. (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4318905-A | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues | SYNTEX (U.S.A.) INC. (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0042753-A1 | Nonapeptide and decapeptide agonists of luteinizing hormone releasing hormone containing heterocyclic amino acid residues, methods for their preparation, pharmaceutical compounds containing them, and their pharmaceutical use | SYNTEX (U.S.A.) INC. (US) | 1981-12-30 | — | — | EP | disclosed |