Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 12/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | PLD2 | O14939 | 4/20 | 0.50 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482356 | 0.92 | CHRM1 (0.67) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL25291004 | 0.91 | OPRM1 (0.61) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL22122308 | 0.88 | OPRM1 (0.59) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL22090629 | 0.84 | CHRM1 (0.57) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL28604447 | 0.83 | OPRM1 (0.60) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL1760904 | 0.83 | OPRM1 (0.57) | OPRM1CHRM1DRD2SIRT2 | |
| SCHEMBL30825655 | 0.83 | OPRM1 (0.57) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL30870639 | 0.83 | SIRT2 (0.49) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL29364904 | 0.83 | DRD2 (0.64) | OPRM1CHRM1DRD2PLD2PLD1 | |
| SCHEMBL2245042 | 0.83 | OPRM1 (0.57) | OPRM1CHRM1DRD2PLD2PLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470989-A | Neuroleptic n-oxacyclyl-alkylpiperidine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-11 | — | — | US | disclosed |
| EP-0068261-A1 | N-oxacyclyl-alkylpiperidine derivatives, their preparation, pharmaceutical preparations containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-01-05 | — | — | EP | disclosed |
| US-3996362-A | ANTIDEPRESSANTS, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-12-07 | — | — | US | disclosed |
| US-3989707-A | NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-02 | — | — | US | disclosed |