SCHEMBL11104875

SCHEMBL11104875

C[C@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@@]43CO)[C@@H]1CC[C@@H]2C(=O)CO

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.63
CYP3A4 P08684 4/20 0.63
PGR P06401 2/20 0.63
CYP2C19 P33261 1/20 0.63
AR P10275 1/20 0.63
CHRM1 P11229 1/20 0.63
TBXA2R P21731 1/20 0.63
ADRA1A P35348 1/20 0.63
SMN1; SMN2 Q16637 5/20 0.57
LMNA P02545 5/20 0.57
MAPT P10636 3/20 0.57
HSD17B10 Q99714 2/20 0.57
SHBG P04278 2/20 0.57
SERPINA6 P08185 2/20 0.57
MAPK1 P28482 2/20 0.57
ABCB11 O95342 1/20 0.57
CYP19A1 P11511 6/20 0.52
HIF1A Q16665 2/20 0.46
BLM P54132 1/20 0.46
CYP2C9 P11712 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11104861 1.00 ALDH1A1 (0.63) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11099069 0.91 ALDH1A1 (0.57) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL10381553 0.90 CYP3A4 (0.78) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11225925 0.89 ALDH1A1 (0.60) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11105182 0.89 ALDH1A1 (0.57) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11226248 0.87 CYP3A4 (0.59) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11226252 0.87 CYP3A4 (0.59) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11226298 0.86 LMNA (0.61) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11429970 0.85 CYP19A1 (0.57) ALDH1A1CYP3A4PGRCYP2C19AR
SCHEMBL11107618 0.85 ALDH1A1 (0.59) ALDH1A1CYP3A4PGRCYP2C19AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0005758-B1 PROCESS FOR THE SYNTHESIS OF THE HYDROXYACETYL SIDE CHAIN OF PREGNANE STEROIDS, 21-HYDROXY 20-OXO-17 ALPHA PREGNANES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1983-05-18 EP claimed
EP-0011818-B1 MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE CIBA-GEIGY AG (CH) 1983-01-19 EP claimed
US-4309423-A ANTIALDOSTERONES CIBA-GEIGY CORPORATION (US) 1982-01-05 US claimed
US-4261985-A REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST CIBA-GEIGY CORPORATION (US) 1981-04-14 US claimed
EP-0011818-A1 Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture CIBA-GEIGY AG (CH) 1980-06-11 EP claimed
US-4424159-A Process for the synthesis of the hydroxyacetyl side-chain of steroids of the pregnane type, novel 21-hydroxy-20-oxo-17α-pregnane compounds and pharmaceutical preparations containing them CIBA-GEIGY CORPORATION (US) 1984-01-03 US disclosed
EP-0005758-B1 PROCESS FOR THE SYNTHESIS OF THE HYDROXYACETYL SIDE CHAIN OF PREGNANE STEROIDS, 21-HYDROXY 20-OXO-17 ALPHA PREGNANES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1983-05-18 EP disclosed
EP-0011818-B1 MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS BASED ON ALDOSTERONE ANTAGONISTS AND DIURETICS AND PROCESS FOR THEIR MANUFACTURE CIBA-GEIGY AG (CH) 1983-01-19 EP disclosed
US-4309423-A ANTIALDOSTERONES CIBA-GEIGY CORPORATION (US) 1982-01-05 US disclosed
US-4261985-A REDUCED EXCRETION OF POTASSIUM IONS BY INCLUSION OF ALDOSTERONE ANTAGONIST CIBA-GEIGY CORPORATION (US) 1981-04-14 US disclosed
EP-0011818-A1 Medicaments and pharmaceutical compositions based on aldosterone antagonists and diuretics and process for their manufacture CIBA-GEIGY AG (CH) 1980-06-11 EP disclosed
US-4058539-A 4,6,8(14)-Triene steroids STEELE CHEMICALS CO. LTD. (CA) 1977-11-15 US disclosed