Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11105712 | 0.90 | L3MBTL1 (0.44) | PDE5ABRD4EGFRERBB2ERBB4 | |
| SCHEMBL11108346 | 0.88 | PDE5A (0.41) | PDE5APPARDBRD4EGFRERBB2 | |
| SCHEMBL11100661 | 0.88 | PPARD (0.41) | PDE5APPARDBRD4EGFRERBB2 | |
| SCHEMBL11287541 | 0.87 | PPARD (0.40) | PDE5APPARDBRD4EGFRERBB2 | |
| SCHEMBL11292499 | 0.86 | PDE5A (0.41) | PDE5APPARDBRD4EGFRERBB2 | |
| SCHEMBL11111799 | 0.85 | PDE5A (0.39) | PDE5APPARDBRD4EGFRERBB2 | |
| SCHEMBL11104667 | 0.84 | KDM4E (0.46) | BRD4EGFRERBB2ERBB4SLC6A2 | |
| SCHEMBL11104825 | 0.84 | KDM4E (0.36) | GALR3PIK3CDPIK3R1LDHAKMT2A | |
| SCHEMBL11102550 | 0.84 | DRD2 (0.45) | BRD4EGFRERBB2ERBB4GALR3 | |
| SCHEMBL11105892 | 0.83 | BRD4 (0.50) | BRD4EGFRERBB2ERBB4PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4435402-A | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY, LIMITED (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0057440-A1 | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-08-11 | — | — | EP | disclosed |