Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11110068 | 0.98 | KDM4E (0.42) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL9724742 | 0.95 | KDM4E (0.42) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL3216608 | 0.90 | KDM4E (0.44) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| Hydrochloric Acid SCHEMBL11104467 | 0.89 | KDM4E (0.43) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL11259455 | 0.84 | SMN1; SMN2 (0.41) | KDM4EALDH1A1HSD17B10CFTRCYP1A2 | |
| SCHEMBL11255526 | 0.84 | HPGD (0.41) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL3199571 | 0.83 | KDM4E (0.43) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| Hydrochloric Acid SCHEMBL11107107 | 0.82 | KDM4E (0.42) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL9686955 | 0.79 | PPARA (0.41) | TSHR | |
| SCHEMBL3219948 | 0.76 | HSP90AA1 (0.48) | KMT2AALDH1A1HSD17B10CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428963-A | ANTILIPEMIC, ANTIOBESITY | HOFFMANN-LA ROCHE INC. (US) | 1984-01-31 | — | — | US | disclosed |
| US-4317915-A | ANTILIPEMIC, ANTIOBESITY | HOFFMANN-LA ROCHE INC. (US) | 1982-03-02 | — | — | US | disclosed |