Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11255526 | 0.89 | HPGD (0.41) | HSD17B10CYP1A2POLBALDH1A1TSHR | |
| SCHEMBL9724742 | 0.85 | KDM4E (0.42) | SMN1; SMN2HSD17B10CYP1A2POLBTDP1 | |
| SCHEMBL11716144 | 0.85 | LTB4R (0.40) | RXFP1LTB4RALDH1A1TSHRF13A1 | |
| SCHEMBL11720804 | 0.84 | LTB4R (0.38) | RXFP1LTB4RALDH1A1F13A1MAPT | |
| Hydrochloric Acid SCHEMBL11251505 | 0.84 | LTB4R (0.40) | RXFP1LTB4RTSHRF13A1MAPT | |
| SCHEMBL11719884 | 0.82 | LTB4R (0.39) | RXFP1LTB4RALDH1A1F13A1MAPT | |
| SCHEMBL11720544 | 0.82 | POLB (0.34) | SMN1; SMN2LTB4RPOLBTDP1ALDH1A1 | |
| SCHEMBL3216608 | 0.80 | KDM4E (0.44) | RXFP1HSD17B10POLBALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL11104467 | 0.79 | KDM4E (0.43) | RXFP1HSD17B10POLBALDH1A1TSHR | |
| SCHEMBL11718479 | 0.78 | LTB4R (0.39) | RXFP1LTB4RALDH1A1TSHRF13A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360681-A | ANTILIPOLYTIC OR DIETETIC AGENT, INTERMEDIATE FOR BIOTIN | HOFFMANN-LA ROCHE INC. (US) | 1982-11-23 | — | — | US | disclosed |
| US-4299968-A | CHEMICAL INTERMEDIATES FOR BIOTIN AND BLOOD LIPID LOWERING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-11-10 | — | — | US | disclosed |
| US-4029647-A | Synthesis of biotin | HOFFMANN-LA ROCHE INC. (US) | 1977-06-14 | — | — | US | disclosed |
| US-3978084-A | Synthesis of biotin | HOFFMANN-LA ROCHE INC. (US) | 1976-08-31 | — | — | US | disclosed |