Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | GRK6 | P43250 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11110073 | 0.95 | KDM4E (0.43) | KDM4EKMT2ATLR8ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL11110068 | 0.94 | KDM4E (0.42) | KDM4EKMT2ATLR8ALDH1A1HSD17B10 | |
| SCHEMBL3216608 | 0.89 | KDM4E (0.44) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| Hydrochloric Acid SCHEMBL11104467 | 0.88 | KDM4E (0.43) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL11255526 | 0.85 | HPGD (0.41) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL11259455 | 0.85 | SMN1; SMN2 (0.41) | KDM4EALDH1A1HSD17B10CFTRCYP1A2 | |
| SCHEMBL9686955 | 0.84 | PPARA (0.41) | TSHRGPR35 | |
| SCHEMBL3199571 | 0.82 | KDM4E (0.43) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| Hydrochloric Acid SCHEMBL11107107 | 0.81 | KDM4E (0.42) | KDM4EKMT2AALDH1A1HSD17B10CFTR | |
| SCHEMBL3219948 | 0.75 | HSP90AA1 (0.48) | KMT2AALDH1A1HSD17B10CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5118688-A | TETRAHYDROPYRIDOQUINOLONE DERIVATIVES USEFUL AS ANXIOLYTIC AGENTS | ICI AMERICAS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4975435-A | Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives useful for treating anxiety | ICI AMERICAS INC. (US) | 1990-12-04 | — | — | US | disclosed |