SCHEMBL11111467

SCHEMBL11111467

NNC1=Nc2ccc(Br)cc2C(c2ccccn2)=NC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 1/20 0.52
GABRA3 P34903 10/20 0.47
GABRA2 P47869 7/20 0.47
GABRA1 P14867 6/20 0.47
GABRA5 P31644 5/20 0.47
GABRB2 P47870 5/20 0.47
GABRG2 P18507 5/20 0.32
GABRB3 P28472 5/20 0.32
CYP1A2 P05177 2/20 0.32
RAB9A P51151 1/20 0.32
ATM Q13315 1/20 0.32
CHRM1 P11229 1/20 0.32
CDK1 P06493 1/20 0.31
S100A4 P26447 1/20 0.31
GRM5 P41594 1/20 0.31
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30
POLB P06746 1/20 0.30
CCR1 P32246 1/20 0.30
CCR5 P51681 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11621252 0.91 ADRA1A (0.49) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL11706162 0.88 ADRA1A (0.52) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL11868363 0.86 ADRA1A (0.37) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL11605182 0.86 CYP1A2 (0.45) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL11618080 0.85 ADRA1A (0.38) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL7372472 0.84 ADRA1A (0.58) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL24127983 0.83 ADRA1A (0.50) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL11728322 0.83 ADRA1A (0.50) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL7313069 0.83 ADRA1A (0.50) ADRA1AGABRA3GABRA2GABRA1GABRA5
SCHEMBL11830130 0.83 ADRA1A (0.47) ADRA1AGABRA3GABRA2GABRA1GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4107159-A Acetal hydrazones of 2-hydrazino-3H-1,4-benzodiazepine THE UPJOHN COMPANY (US) 1978-08-15 US claimed
US-4455307-A Antihypertensive use of triazolobenzodiazepines THE UPJOHN COMPANY (US) 1984-06-19 US disclosed
EP-0087850-A1 Benzodiazepines for anti-hypertensive use THE UPJOHN COMPANY (US) 1983-09-07 EP disclosed
US-4107159-A Acetal hydrazones of 2-hydrazino-3H-1,4-benzodiazepine THE UPJOHN COMPANY (US) 1978-08-15 US disclosed
US-4086230-A 1,5-Dihydro-7-aryl-as-triazine[4,3,-α][1,4]benzodiazepin-1-ols THE UPJOHN COMPANY (US) 1978-04-25 US disclosed
US-4081452-A Novel derivatives of 4H-s-triazolo[4,3-α][1,4]benzodiazepines THE UPJOHN COMPANY (US) 1978-03-28 US disclosed
US-4073785-A Certain as-triazino 4,3-a! 1,4!benzodiazepine derivatives THE UPJOHN COMPANY (US) 1978-02-14 US disclosed
US-4073784-A Certain as-triazino 4,3-a! 1,4!benzodiazepine-1,2-dione compounds THE UPJOHN COMPANY (US) 1978-02-14 US disclosed
US-4044016-A ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS HOFFMANN-LA ROCHE INC. (US) 1977-08-23 US disclosed
US-4039551-A 1-[(Hydroxyamino)methyl]-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines THE UPJOHN COMPANY (US) 1977-08-02 US disclosed
US-4028356-A Triazinobenzodiazepines THE UPJOHN COMPANY (US) 1977-06-07 US disclosed
US-4017492-A As-triazinobenzodiazepin-1-ones THE UPJOHN COMPANY (US) 1977-04-12 US disclosed
US-4016165-A Triazino benzodiazepines THE UPJOHN COMPANY (US) 1977-04-05 US disclosed
US-4009175-A 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines THE UPJOHN COMPANY (US) 1977-02-22 US disclosed
US-3996230-A 1-Piperazino-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepines THE UPJOHN COMPANY (US) 1976-12-07 US disclosed
US-3995043-A BENZODIAZEPINE DERIVATIVES FOR TREATING ANXIETY AND DEPRESSION THE UPJOHN COMPANY (US) 1976-11-30 US disclosed
US-3970664-A ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE HOFFMANN-LA ROCHE INC. (US) 1976-07-20 US disclosed
US-3954728-A ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES HOFFMAN-LA ROCHE INC. (US) 1976-05-04 US disclosed