Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 14/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8186745 | 0.77 | IDH1 (0.43) | P2RX7ADAMTS4MMP13ADRB1 | |
| SCHEMBL1118071 | 0.77 | ACACB (0.43) | ACACB | |
| SCHEMBL4664170 | 0.77 | NPSR1 (0.70) | P2RX7ADAMTS4MMP13ADRB1NPSR1 | |
| SCHEMBL29676316 | 0.75 | ACACB (0.53) | ACACBP2RX7ADRB1NPSR1 | |
| SCHEMBL1111196 | 0.74 | HTR2A (0.47) | P2RX7ADAMTS4MMP13ADRB1 | |
| SCHEMBL26046016 | 0.74 | P2RX7 (0.49) | P2RX7ADAMTS4MMP13ADRB1NPSR1 | |
| Hydrochloric Acid SCHEMBL1111187 | 0.73 | HTR2A (0.46) | P2RX7ADAMTS4MMP13ADRB1 | |
| SCHEMBL19837388 | 0.73 | P2RX7 (0.47) | ACACBP2RX7ADAMTS4MMP13ADRB1 | |
| SCHEMBL8256625 | 0.73 | P2RX7 (0.41) | P2RX7ADAMTS4MMP13ADRB1 | |
| SCHEMBL3823658 | 0.72 | ACACB (0.52) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |