Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 8/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1111187 | 0.98 | HTR2A (0.46) | HTR2AHTR2CHTR2BP2RX7SLC6A2 | |
| SCHEMBL8186745 | 0.86 | IDH1 (0.43) | P2RX7MBOAT4IDH1ADRB1ADAMTS4 | |
| SCHEMBL8256625 | 0.81 | P2RX7 (0.41) | P2RX7MBOAT4IDH1ADRB1ADAMTS4 | |
| SCHEMBL21503525 | 0.79 | ADRB1 (0.40) | HTR2CHTR2BP2RX7SLC6A4ADORA2A | |
| SCHEMBL24974270 | 0.79 | IDH1 (0.42) | P2RX7MBOAT4IDH1ADRB1ADAMTS4 | |
| SCHEMBL18158044 | 0.76 | ADRB1 (0.42) | HTR2AHTR2CHTR2BP2RX7SLC6A4 | |
| SCHEMBL28280047 | 0.76 | IDH1 (0.43) | P2RX7SLC6A2SLC6A4SLC6A3ADORA2A | |
| SCHEMBL317403 | 0.76 | P2RX7 (0.47) | HTR2CHTR2BP2RX7SLC6A4ADORA2A | |
| SCHEMBL2324124 | 0.76 | P2RX7 (0.43) | HTR2CHTR2BP2RX7SLC6A4ADORA2A | |
| SCHEMBL13167431 | 0.75 | IDH1 (0.47) | P2RX7ADORA2AIDH1ADRB1ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |