Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | CBLB | Q13191 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29676316 | 0.81 | ACACB (0.53) | ADRB1P2RX7ACACBNPSR1IDH1 | |
| SCHEMBL1111249 | 0.78 | NPSR1 (0.42) | ACACBNPSR1MTNR1AMTNR1B | |
| SCHEMBL22481243 | 0.78 | ADRB1 (0.72) | ADRB1P2RX7IDH1 | |
| SCHEMBL23343865 | 0.77 | ADRB1 (0.54) | ADRB1P2RX7IDH1 | |
| SCHEMBL1118073 | 0.77 | ACACB (0.39) | ACACBSYKMTNR1AMTNR1BIDH1 | |
| SCHEMBL15354799 | 0.76 | ADRB1 (0.51) | ADRB1P2RX7IDH1 | |
| SCHEMBL29675917 | 0.75 | ADRB1 (0.49) | ADRB1P2RX7ACACBSYKIDH1 | |
| SCHEMBL20342872 | 0.74 | ADRB1 (0.54) | ADRB1P2RX7ACACBIDH1 | |
| SCHEMBL27825130 | 0.74 | ADRB1 (0.47) | ADRB1P2RX7ACACBNPSR1IDH1 | |
| SCHEMBL4664170 | 0.74 | NPSR1 (0.70) | ADRB1P2RX7NPSR1SYKDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |