Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1111317 | 0.81 | PCSK9 (0.44) | IRAK4ACACB | |
| SCHEMBL2784760 | 0.80 | STAT3 (0.40) | IRAK4ACACB | |
| SCHEMBL1111155 | 0.78 | ADRB1 (0.52) | NPSR1MTNR1AMTNR1BACACB | |
| SCHEMBL16198036 | 0.74 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL15354786 | 0.73 | IRAK4 (0.49) | IRAK4 | |
| SCHEMBL16397013 | 0.73 | STAT3 (0.42) | IRAK4ALDH1A1HPGD | |
| SCHEMBL2771153 | 0.73 | IRAK4 (0.41) | NPSR1IRAK4ALDH1A1HPGD | |
| SCHEMBL16197565 | 0.73 | IRAK4 (0.36) | IRAK4HPGD | |
| SCHEMBL1111000 | 0.72 | TAAR1 (0.41) | IRAK4 | |
| SCHEMBL906765 | 0.72 | IRAK4 (0.39) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278968-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009131814-A2 | 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS | ELI LILLY AND COMPANY (US) | 2009-10-29 | — | — | WO | disclosed |