Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 20/20 | 0.54 |
| ▸ | CNR1 | P21554 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11112882 | 0.93 | CNR2 (0.60) | CNR2CNR1 | |
| SCHEMBL11101488 | 0.91 | CNR2 (0.47) | CNR2CNR1CYP1A2HPGDTSHR | |
| SCHEMBL11101596 | 0.83 | KMT2A (0.51) | CNR2HPGDCYP2C19MEN1ALDH1A1 | |
| SCHEMBL11109604 | 0.76 | CNR2 (0.36) | CNR2TSHRMEN1ALDH1A1MAPT | |
| SCHEMBL29385119 | 0.70 | CNR2 (1.00) | CNR2CNR1 | |
| SCHEMBL11155890 | 0.70 | CNR2 (0.70) | CNR2CNR1CYP1A2HPGDTSHR | |
| SCHEMBL497044 | 0.69 | CNR2 (1.00) | CNR2CNR1CYP1A2HPGDTSHR | |
| SCHEMBL29387466 | 0.69 | CNR2 (1.00) | CNR2CNR1CYP1A2HPGDTSHR | |
| SCHEMBL6325774 | 0.69 | CNR2 (1.00) | CNR2CNR1CYP1A2HPGDTSHR | |
| SCHEMBL11155933 | 0.69 | CNR2 (0.73) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377698-A | 2,4 Bis(2-indolyl-3)-4-oxobutanoic acids | STERLING DRUG INC. (US) | 1983-03-22 | — | — | US | claimed |
| US-4477676-A | 4-(3-Indolyl)-2,3-dichloro-4-oxo-2-butenoic acids | THE HILTON-DAVIS CHEMICAL CO. (US) | 1984-10-16 | — | — | US | disclosed |
| US-4377698-A | 2,4 Bis(2-indolyl-3)-4-oxobutanoic acids | STERLING DRUG INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4275121-A | Carbonless duplicating and marking systems utilizing indolyl-substituted furanone color formers | STERLING DRUG INC. (US) | 1981-06-23 | — | — | US | disclosed |
| US-4075224-A | 3,5-Bis (indolyl)-5-(indolyl)-2(5H)-furanones | STERLING DRUG INC. (US) | 1978-02-21 | — | — | US | disclosed |