Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11111567 | 0.83 | CNR2 (0.54) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL11101488 | 0.82 | CNR2 (0.47) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL11112882 | 0.81 | CNR2 (0.60) | CNR2 | |
| SCHEMBL11109604 | 0.80 | CNR2 (0.36) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL28836465 | 0.76 | KDM4E (0.53) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL14397448 | 0.75 | ALDH1A1 (0.67) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL30443220 | 0.74 | EGFR (0.65) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL984736 | 0.74 | EGFR (0.65) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL8702816 | 0.71 | KMT2A (0.62) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL7278316 | 0.71 | EGFR (0.65) | KMT2AMEN1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4477676-A | 4-(3-Indolyl)-2,3-dichloro-4-oxo-2-butenoic acids | THE HILTON-DAVIS CHEMICAL CO. (US) | 1984-10-16 | — | — | US | disclosed |
| US-4451657-A | 3,5- And 5,5-bis(3-indolyl)-2-(5H)furanones | THE HILTON-DAVIS CHEMICAL CO. (US) | 1984-05-29 | — | — | US | disclosed |
| US-4377698-A | 2,4 Bis(2-indolyl-3)-4-oxobutanoic acids | STERLING DRUG INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4275121-A | Carbonless duplicating and marking systems utilizing indolyl-substituted furanone color formers | STERLING DRUG INC. (US) | 1981-06-23 | — | — | US | disclosed |
| US-4075224-A | 3,5-Bis (indolyl)-5-(indolyl)-2(5H)-furanones | STERLING DRUG INC. (US) | 1978-02-21 | — | — | US | disclosed |