Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.61 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 4/20 | 0.45 |
| ▸ | MASP2 | O00187 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11108769 | 0.96 | APP (0.57) | APPHSD17B1HSD17B2NQO2IKBKB | |
| SCHEMBL23566334 | 0.81 | NQO2 (0.71) | APPNQO2IKBKBPLAUMASP2 | |
| SCHEMBL4711536 | 0.78 | RAB9A (0.70) | APPHSD17B1HSD17B2IKBKBKDM4E | |
| SCHEMBL23566269 | 0.78 | PLAU (0.50) | NQO2IKBKBPLAUF2KDM4E | |
| SCHEMBL6751854 | 0.78 | APP (1.00) | APPHSD17B1HSD17B2NQO2ALDH1A1 | |
| SCHEMBL11106853 | 0.75 | APP (0.66) | APPNQO2IKBKBPLAUPRSS1 | |
| SCHEMBL31237738 | 0.75 | APP (0.65) | APPHSD17B1HSD17B2NQO2IKBKB | |
| SCHEMBL23566322 | 0.73 | NQO2 (0.59) | NQO2ALDH1A1 | |
| SCHEMBL7259715 | 0.73 | APP (0.53) | APPHSD17B1HSD17B2IKBKBKDM4E | |
| SCHEMBL5307850 | 0.72 | NQO2 (0.85) | APPNQO2PLAUMASP2THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4424367-A | 5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-01-03 | — | — | US | claimed |