Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892984 | 0.81 | POLB (0.54) | ALDH1A1KMT2ATDP1CYP1A2CYP3A4 | |
| SCHEMBL6997448 | 0.80 | GLA (0.52) | GLANPSR1ALDH1A1ATMHSD17B10 | |
| SCHEMBL11112763 | 0.78 | ESR1 (0.49) | NPSR1ABL1MAPK1KMT2ATDP1 | |
| SCHEMBL14687147 | 0.77 | CA12 (0.53) | ABL1ALDH1A1HPGDMAPTRAB9A | |
| SCHEMBL16480425 | 0.77 | HRH3 (0.43) | ABL1ALDH1A1HPGDHTTLMNA | |
| SCHEMBL9893024 | 0.77 | HCRTR1 (0.43) | ABL1MAPTKMT2ATDP1HRH3 | |
| SCHEMBL4636834 | 0.76 | GAA (0.46) | ABL1LMNARAB9AKMT2AGAA | |
| SCHEMBL16480399 | 0.75 | CCNA2 (0.40) | ABL1ALDH1A1MAPTRAB9ATDP1 | |
| SCHEMBL25416662 | 0.74 | ALDH1A1 (0.42) | ABL1ALDH1A1MAPTKMT2AGAA | |
| SCHEMBL22658820 | 0.74 | SLC6A2 (0.46) | ABL1ALDH1A1HSD17B10HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | claimed |
| EP-0106988-A1 | Pharmacologically active lactam derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-05-02 | — | — | EP | disclosed |