Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691782 | 0.84 | KMT2A (0.47) | KMT2AMEN1TNKSHDAC1HDAC8 | |
| SCHEMBL10570755 | 0.81 | GLA (0.48) | GLAKMT2AMEN1ATMTDP1 | |
| SCHEMBL3739324 | 0.80 | HDAC6 (0.54) | TNKSHDAC1HDAC8HDAC6CCNA2 | |
| SCHEMBL11113574 | 0.80 | GLA (0.59) | GLAKMT2AATMNPSR1CCNA2 | |
| SCHEMBL3586685 | 0.78 | ALDH1A1 (0.49) | TNKSHDAC1HDAC8HDAC6CCNA2 | |
| SCHEMBL14155611 | 0.78 | HDAC1 (0.55) | KMT2AMEN1TNKSHDAC1HDAC8 | |
| SCHEMBL3584808 | 0.78 | ALDH1A1 (0.49) | TNKSHDAC1HDAC8HDAC6CCNA2 | |
| SCHEMBL6783997 | 0.77 | CCNA2 (0.60) | KMT2AMEN1TNKSHDAC1HDAC8 | |
| SCHEMBL10574183 | 0.76 | TDP1 (0.55) | KMT2AMEN1TDP1ALDH1A1GFER | |
| SCHEMBL5591295 | 0.76 | LMNA (0.53) | TNKSHDAC1HDAC8HDAC6CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345909-A1 | PHENYLACETAMIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002048114-A1 | PHENYLACETAMIDO- PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2002-06-20 | — | — | WO | disclosed |