Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9445045 | 0.98 | ALDH1A1 (0.39) | HDAC8ALDH1A1MEN1APOBEC3ARAB9A | |
| Bromide SCHEMBL11771357 | 0.83 | HDAC8 (0.36) | HDAC8ALDH1A1TDP1TP53 | |
| Bromide SCHEMBL11500386 | 0.82 | CA1 (0.36) | HDAC8ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL31229957 | 0.81 | HDAC8 (0.37) | HDAC8ALDH1A1TDP1CA1CA2 | |
| SCHEMBL9483912 | 0.81 | HDAC8 (0.37) | HDAC8ALDH1A1TDP1CA1CA2 | |
| Water SCHEMBL9445008 | 0.79 | HDAC8 (0.36) | HDAC8ALDH1A1TDP1TP53 | |
| Hydrochloric Acid SCHEMBL9819638 | 0.74 | CA1 (0.52) | HDAC8ALDH1A1RAB9ACA1CA2 | |
| SCHEMBL4347854 | 0.71 | HDAC8 (0.47) | HDAC8ALDH1A1TDP1TP53 | |
| SCHEMBL10882027 | 0.71 | ALDH1A1 (0.45) | HDAC8ALDH1A1MEN1APOBEC3AKMT2A | |
| SCHEMBL1560541 | 0.71 | TDP1 (0.38) | HDAC8ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0108605-A2 | Apparatus for detecting particles and changes in particle size in a suspension | UNIVERSITY COLLEGE LONDON (GB) | 1984-05-16 | — | — | EP | disclosed |