Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9445045 | 0.75 | ALDH1A1 (0.39) | CA1CA2ALDH1A1TSHRHDAC8 | |
| SCHEMBL31229957 | 0.74 | HDAC8 (0.37) | CA1CA2ALDH1A1KDM4EHDAC8 | |
| Bromide SCHEMBL11113776 | 0.74 | HDAC8 (0.37) | CA1CA2ALDH1A1HDAC8RAB9A | |
| SCHEMBL9483912 | 0.74 | HDAC8 (0.37) | CA1CA2ALDH1A1KDM4EHDAC8 | |
| Water SCHEMBL9445008 | 0.73 | HDAC8 (0.36) | ALDH1A1KDM4EHDAC8TP53 | |
| Bromide SCHEMBL11771357 | 0.73 | HDAC8 (0.36) | ALDH1A1KDM4EHDAC8GAATP53 | |
| Hydrochloric Acid SCHEMBL637319 | 0.70 | RAB9A (0.52) | CA1CA2ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL29754142 | 0.70 | RAB9A (0.52) | CA1CA2ALDH1A1KDM4ELMNA | |
| Bromide SCHEMBL11500386 | 0.69 | CA1 (0.36) | CA1CA2ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL1884052 | 0.68 | CA1 (0.46) | CA1CA2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492510-B2 | Protective graft coating for application onto polyurethane for chemical resistance, stain resistance, abrasion resistance and U.V. resistance | ERGOCENTRIC INC. (CA) | 2022-11-08 | — | — | US | disclosed |
| WO-2021030069-A1 | IMPROVED CUTTING BLADES | CRESCENT MANUFACTURING COMPANY (US) | 2021-02-18 | — | — | WO | disclosed |
| US-20210041331-A1 | CUTTING BLADES | CRESCENT MANUFACTURING COMPANY | 2021-02-11 | — | — | US | disclosed |
| US-20180362800-A1 | PROTECTIVE GRAFT COATING FOR APPLICATION ONTO POLYURETHANE FOR CHEMICAL RESISTANCE, STAIN RESISTANCE, ABRASION RESISTANCE AND U.V. RESISTANCE | ERGOCENTRIC INC. (CA) | 2018-12-20 | — | — | US | disclosed |
| US-9845406-B2 | Method and composition re polyurethane seating | ERGOCENTRIC INC. (CA) | 2017-12-19 | — | — | US | disclosed |
| US-20140335362-A1 | METHOD AND COMPOSITION RE POLYURETHANE SEATING | ERGOCENTRIC INC. (CA) | 2014-11-13 | — | — | US | disclosed |
| US-5009880-A | Mixture of an anionic and cationic polymer for shampoos, skin lotions, nail strengtheners and hair dyeing; improved fixing and anchoring; smoothness; gloss | L'OREAL (FR) | 1991-04-23 | — | — | US | disclosed |
| US-4719099-A | ANIONIC AND CATIONIC | L'OREAL (FR) | 1988-01-12 | — | — | US | disclosed |
| US-4445521-A | ANIONIC AND CATIONIC POLYMER COMBINATION | L'OREAL (FR) | 1984-05-01 | — | — | US | disclosed |
| US-4304563-A | SHAMPOO OR CONDITIONER TO PREVENT OILY HAIR | SOCIETE ANONYNE DITE: L'OREAL (FR) | 1981-12-08 | — | — | US | disclosed |
| US-4247615-A | DIAZO RESIN, MORDANT FOR ANIONIC DYE | EASTMAN KODAK COMPANY (US) | 1981-01-27 | — | — | US | disclosed |
| US-4240450-A | HAIR CONDITIONER OF ANIONIC POLYMERS AND CATIONIC POLYMERS | L'OREAL (FR) | 1980-12-23 | — | — | US | disclosed |
| US-4220700-A | MORDANTS, ANIONIC DYES | EASTMAN KODAK COMPANY (US) | 1980-09-02 | — | — | US | disclosed |
| US-3962527-A | Novel polymers and photographic elements containing same | EASTMAN KODAK COMPANY (US) | 1976-06-08 | — | — | US | disclosed |