Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11110377 | 0.86 | MCL1 (0.55) | FOLH1CHRM4CHRM3CLCN2MCL1 | |
| SCHEMBL29556926 | 0.86 | MCL1 (0.55) | FOLH1CHRM4CHRM3CLCN2MCL1 | |
| SCHEMBL17192030 | 0.85 | GSK3B (0.44) | SMN1; SMN2MAPTCYP2C9CYP2C19PDE4D | |
| SCHEMBL11112757 | 0.85 | CHRM4 (0.48) | FOLH1CHRM4CHRM3CLCN2MCL1 | |
| SCHEMBL11847933 | 0.84 | MCL1 (0.46) | FOLH1CHRM4CHRM3CLCN2MCL1 | |
| SCHEMBL5893910 | 0.84 | L3MBTL1 (0.54) | FOLH1MCL1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL11817706 | 0.83 | PDE4D (0.52) | FOLH1L3MBTL1SMN1; SMN2MAPTCYP2C9 | |
| SCHEMBL23067188 | 0.81 | HDAC6 (0.51) | CHRM4CHRM3CLCN2MCL1L3MBTL1 | |
| SCHEMBL21436903 | 0.81 | L3MBTL1 (0.58) | FOLH1MCL1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL29557588 | 0.81 | HDAC6 (0.51) | CHRM4CHRM3CLCN2MCL1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4470997-A | Esters | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-09-11 | — | — | US | disclosed |
| US-4423070-A | DI- AND TRIESTERS OF N-(ACYLAMINOALKYL)-DIHYDROXYPHENYLETHANOLAMINES, ANTIINFLAMMATORY | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1983-12-27 | — | — | US | disclosed |