Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.67 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | RET | P07949 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | CDK8 | P49336 | 1/20 | 0.67 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11118397 | 0.83 | AURKB (0.70) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11120834 | 0.82 | AURKB (0.67) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11114055 | 0.80 | KMT2A (0.49) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11116147 | 0.79 | JAK2 (0.55) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11119913 | 0.78 | KDR (0.48) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11116148 | 0.78 | LMNA (0.57) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11119210 | 0.77 | CYP1A2 (0.50) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11119091 | 0.77 | NTRK1 (0.70) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11119331 | 0.76 | LMNA (0.60) | AURKBNTRK1NTRK2JAK2RET | |
| SCHEMBL11121541 | 0.75 | JAK2 (0.50) | AURKBNTRK1NTRK2JAK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |